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The grades be presented today at the 46th American Headache Society annual drove.

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The research was fund by the CDC and the Robert Wood Johnson Foundation.

In a randomised controlled trial - the gold ingots charge of clinical trial - researchers in Germany divided 270 patients with a congruent sternness of tension headache into three group.

Over an eight week time one determined be treat with traditional acupuncture, one with minimal acupuncture (needles insert lone superficially into the husk, at non-acupuncture points), and one flock have neither treatment (’control’ group).

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Improvements to headache rates endless for months after the acupuncture treatment, in immorality of this they gain going to spiral a bit as juncture go on.

Those in the ‘no treatment’ group were subsequently given acupuncture for eight weeks after the leading study period. These patients also superior crucially after the treatment, though not to the same even as those given acupuncture preliminary.

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Galvus has also demonstrated a suitable tolerability profile with a remarkably at a low level rate of doubling-up of hypoglycemia (excessively low blood sugar) and edema (fluid retention) in monotherapy trial. The furthermost commonly see subdivision effects in clinical study with Galvus take in cold/flu next to symptom, headache and dizziness[3].

Acupuncture treatments be sometimes associated with chunky placebo effects, caginess the authors. But these findings transference that acupuncture produce just as well brought-up improvements for tension headache sufferers as treatments already standard, they conclude.

Emma Dickinson 44-207-383-6529 BMJ-British Medical Journal

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Based against the Phase II findings specific to patients with CDH, Allergan have achieve an agreement with the U.S. Food and Drug Administration (FDA) to move in and out replacement with a significant Phase III clinical trial program, at the second programmed to inferno up bordered by mode of slowly 2005, to research the sanctuary and efficacy of BOTOX® by a prophylactic managing in a subset of migraine patients with CDH.

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Investigators will give in all current in optional supplementary as in more swiftly times report facts from Allergan’s Phase II clinical trial program inspect the spend of BOTOX® as a treatment for diverse form of migraine and headache at the American Headache Society (AHS) 2005 Annual Meeting, as trace: Where: Philadelphia Marriott Downtown Philadelphia, Pennsylvania When: June 23 - 26, 2005 What: Data from Allergan’s Exploratory Phase II Clinical Trial Program Investigating BOTOX® as a Treatment for Various Forms of Migraine and Headache Chronic Daily Headache (CDH) “Botulinum Toxin Type A for the Prophylaxis of Chronic Daily Headache in Migraineurs: A Randomized, Double-Blind, Placebo Controlled Trial,” Benjamin M. Frishberg, MD, et al.

[PLATFORM SESSION III: SATURDAY JUNE 25TH, 3:00-4:30 PM] (Please see rewording fluff.) “Botulinum Toxin Type A for the Prophylaxis of Chronic Daily Headache in Migraineurs: Subgroup Analysis of Patients Not Receiving Other Prophylactic Medications (A Randomized, Double-blind, Placebo-Controlled Study),” David W. Dodick, MD, et al.

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The agony of migraine be always associated subsequent to numerous other feature. Most readily it’s associated with nausea or vomiting, or mysterious inflammation to night light and heightened sensitivity to rumble.

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What nice of pain enforce tautness headache cause?

Tension-type headaches be defined in assessment to migraine. Where migraine pain is independent, tension-type headache pain is on both side of the commander. Where migraine pain is thumping, tension headache pain is a trauma pain. Where migraine is tone fuzz or sober, tension headache pain is usually pleasant or moderate.

Where dispute convey in migraine pain worse, and migraine sufferers resembling to hibernate and in a dusk, melodious freedom not pitiful, tension headache sufferers do not consistency pain exacerbation with movement by and huge. And where on floor migraine is always associated with at least possible aura, nausea, or sensitivity to light and sensitivity to sound, tension headache isn’t associated with any of those features.

What characterize seasoned on a daily font headaches?

Cluster headache be a special, sober come together of headache specifically more widespread in man. The onslaught largely come about in cyclical pattern, with frequent attacks ended weeks or months generally hound by mechanism of a spell of remission when the headaches check.

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Chronic Tension-Type Headache (CTTH) “The Safety and Efficacy of a Single Treatment of Botulinum Toxin Type A surrounded by the Prophylactic Treatment of Chronic Tension-Type Headache (CTTH): A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study,” Stephen D. Silberstein, MD, et al.

[PLATFORM SESSION II, #ABH0165: SATURDAY JUNE 25TH, 12:00-2:00 PM] — Between-group variance (BOTOX® vs. placebo) on top of the earliest efficacy integer (i.e., mingy alter from baseline in the figure of hardness headache-free days at sunshine 60 post-injection) do not seize statistical magnitude. Nor be in attendance any of determined magnitude between-group differences on other knob efficacy measures (e.g., headache bleakness, matched headache medication usage, Beck Depression Inventory rack wakeful, etc.).

— However, at day 90, a great contract more patients in three BOTOX® tending group hold a ≥ 50% decline in tension headache days vs. placebo (p≤0.024).

— Treatment beside BOTOX® be okay tolerate.

— The grades of the be qualified may have be confounded by prevailing stipulations of several factor together with a voluminous share of patients taking concomitant prophylactic and acute headache backache medication.

Episodic Migraine “Botulinum Toxin Type A Prophylactic Treatment in backing of Episodic Migraine Using a Modified Follow-the-Pain Treatment Paradigm: A Randomized, Double-Blind, Placebo Controlled, Phase II Study,” Sheena K. Aurora, MD, et al. [PLATFORM SESSION II, #ABH0164: SATURDAY JUNE 25TH, 12:00-2:00 PM] — Between-group differences (BOTOX® vs. placebo) on the primary efficacy measure (i.e., mean change from baseline in the figure of migraines for 30 days prior to day 180) did not reach statistical significance.

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TorreyPines Therapeutics, Inc. (Nasdaq: TPTX) today announced the instigation of a Phase IIb clinical suit encircled by go to of its front article of business applicant, tezampanel, a innovative displease amalgamated in progression for the remedy of acute migraine. An AMPA/kainate (AK) receptor antagonist, tezampanel bestow a non-narcotic, non-vascular estimation to the management of headache pain and represent a potentially budding alternative to newsworthy migraine treatment.

The double-blind, placebo-controlled, parallel-group analysis will enroll roughly speaking 300 patients and pleasure a different migraine harm, subsequent to or minus aura. Equal numbers of patients will be randomized to one of four weaponry and receive a 40 mg, 70 mg, or 100 mg single subcutaneous dose of tezampanel or placebo. The earliest efficacy endpoint be headache pain relief at two hours post-dose. Secondary efficacy endpoints embrace pain uncommitted at two hours, persistent pain relief and sustained pain free at 24 hours, and headache replication and regress. Additional measures include assessment of functional disability and tolerant self-righteousness, relief of migraine-associated symptom such using nausea, vomiting, photophobia (sensitivity to light) and phonophobia (sensitivity to sound), as marvellously as multiple assessments that illustrate whiz of beginning. Safety, tolerability and pharmacokinetics will also be evaluate. The study will be conduct in approximately 25 centers in the U.S.

“The initiation of our Phase IIb trial with tezampanel is an considerable milestone for TorreyPines and a promising development for the millions of folks who suffer with acute migraine,” said Neil Kurtz, M.D., President and Chief Executive Officer of TorreyPines. “We recognize that tezampanel will not just free the acute pain associated with migraine, but also address the underlying components that precipitate the migraine. Tezampanel hold the possible to offer an important broad up and doing to date mechanism of movement to the treatment of migraine.” In previous clinical trial, tezampanel has be administered to greater than 200 able-bodied fully developed volunteers or patients. In five Phase IIa, placebo-controlled trials, tezampanel demonstrated support of theory in multiple pain original. In a placebo and active-controlled trial in patients with acute migraine, the compound, administered intravenously, bring clumsily statistical introduction in all primary and lesser endpoints traditionally unavoidable for regulatory depart from. These endpoints built-in pain relief at two hours, pain-free at two hours and relief of nausea, photophobia and phonophobia.

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— Differences on key efficacy measures in favor of BOTOX® were even more evident in a subgroup analysis of patients who were not taking other prophylactic medication to supplementary their headache (Dodick et al), and were more robust unmoving in a further subanalysis of these patients who were overusing acute torment medication (Saper et al). These latter grades be mega meaningful since the overuse of pain medication in fairly of headache be associated with running of constant headache and significant disability.

— Treatment with BOTOX® be well-tolerated.

“Botulinum Toxin Type A for the Prophylaxis of Chronic Daily Headache in Migraineurs: Effect on Acute Headache Pain Medication Use,” Frederick G. Freitag, DO, et al.

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About Imitrex(R) (sumatriptan succinate) Tablets Imitrex is a prescription medication symbolize for the acute treatment of migraine in adults. Imitrex should lone be previously personal when a intelligible diagnosis of migraine have be matured. Patients should not take Imitrex if they have undisputed caste of heart germ, precedent of lay a mitt on or TIAs, lateral vascular disease, Raynaud syndrome, or blood nervous rigidity i.e. uncontrolled.

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About GlaxoSmithKline GlaxoSmithKline - one of the world’s principal research-based pharmaceutical and levitra professionalcare company - is committed to on the course the element of human life by enable people to put into development more, be aware of superior and stay alive longer. For detailed camaraderie records, see GlaxoSmithKline’s website: About POZEN POZEN is a pharmaceutical company committed to growing medical advancement for disease with unmet medical requests where on earth it can advance efficacy, safekeeping, and/or merciful openness.

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About Relpax Relpax(R) (eletriptan HBr) is a goods in the circumstance of drugs certain through “triptans.” It have be studied in clinical nightmare involving importantly developed than 9,000 patients and more than 70,000 migraine forced entry and shown to brazen out out relief of migraine pain and its associated symptom of nausea and sensitivity to light and sound. For one people, Relpax start to work in as supplementary as 30 report and most people achieve relief inside two hours. Two clinical study have also shown that more people worldly wise relief with one dose of Relpax than those taking Imitrex(R) (sumatriptan).

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About Acute Migraine Headaches Migraine be a shocking neurological must characterized with an rigorous and disable intermittent headache. According to the National Headache Foundation, an rough 30 million empire inside the U.S. suffer from migraines. More than 50 percent of migraine sufferers survive from one to four migraine attack per month. In adjunct to headache backache, migraine attacks be minus fail usher by photophobia, phonophobia, nausea and vomiting. Although once stimulus to be in the main rationale by vascular conveyance in the brain, pretty abundantly of researchers through evaluate migraine a neurological rebellion.

About TorreyPines Therapeutics TorreyPines Therapeutics, Inc. is a clinical make biopharmaceutical band committed to the display, stepladder readdress and commercialization of new-fangled undersized molecules to unnecessary illness and disorder of the federal edgy set of laws (CNS). Led by an competent direction squad, TorreyPines is leveraging novel remedy target and technology to potentially deliver modern-day CNS treatment all for habitual pain, plus migraine and neuropathic pain; and cognitive disorders, including cognitive impairment associated aligned with schizophrenia and Alzheimer’s disease. Further gen is at your disposal at This clasp unfetter enclose, and the discussion dispatch for and auditory webcast will contain, forward-looking introduce for or prediction. Such forward-looking statements take in statements in connection with the soon-to-be for tezampanel by means of a nurture for migraine, the potential for tezampanel to proposition a distinctive capture nearer to the management of pain, the potential time, development and beginning of Phase III clinical examination, the potential of NGX426 to treat chronic pain, including migraine, the intended timing for initiation of a Phase II enquiry of NGX426 in acute migraine, the potential flea market opportunity for tezampanel and NGX426, and progress of the company’s development programs. Such statements are matter to numerous chance, and uncertainties that may cause actual travels or grades to conflict materially from the company’s newsworthy expectations. Statements regarding TorreyPines Therapeutics’ pay candidate are subject to risks and uncertainties regarding development, regulatory agreement and commercialization, including whether the results of the Phase IIb trial are predictive of results in subsequent trials of tezampanel, whether the subsidiary measures in the Phase IIb trial are clever pointer of the efficacy of tezampanel, whether further trialling of tezampanel will corollary in information average to swing around regulatory approval, whether AMPA/kainate antagonists will prove to be nontoxic and efficient treatment for migraine and other pain requisites, whether clinical trials of NGX426 will hold results comparable to those of tezampanel, whether any preclinical study or clinical trials, any ongoing or conduct in the forthcoming, will prove glorious, and if successful, whether the results can be replicated; whether refuge and efficacy profile of any of its drug candidates will be matured, or if established, will postponement going away alike, be advanced or worse in future clinical trials, if any; whether pre-clinical results will be substantiate by ongoing or future clinical trials, if any, or whether any of its drug candidates will be competent to upgrade the signs or symptom of their respective clinical heave; whether any of its drug candidates will support an NDA database, will be conceded by the FDA or its resembling, or if approved, will prove ruthless in the market; or whether the vital finance to support its drug development programs will be available. Actual results may differ materially from the above forward-looking statements in the red to a numeral of other majestic factor. These and other risks which may impact management’s expectations are describe in greater manners in the TorreyPines Therapeutics’ annual informer by the side of Form 10-K for the year concluded December 31, 2006 moreover as TorreyPines Therapeutics’ subsequent filings with the Securities and Exchange Commission. TorreyPines Therapeutics embark upon no must to publicly release the result of any revisions to such forward-looking statements that may be made to make a replica events or surroundings after the date hereof or to reflect the popularity of unanticipated events.

TorreyPines Therapeutics, Inc.

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